WASD control movement.
Mouse or arrow-keys control the direction the player shoots.
Mobs are moving toward the player which can be troublesome for gamers with disabilities.
The menus can be navigated entirely with a mouse.
Cannot be played with mouse exclusively.
Mouse wheel is not needed.
Fullscreen or windowed.
On-Screen-Keyboard works.
No options for the colorblind.
Sound is not a critical element. All important things are visual.